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Search Results for " tie2 kinase inhibitor "

6

Compounds

Cat No. Product Name Synonyms Targets
T6335 Tie2 kinase inhibitor 1 Tie2 kinase inhibitor Tie-2
Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor), an optimized compound of SB-203580, is selective to Tie2 with IC50 of 0.25 μM, which is 200-fold more effective than p38.
T6154 SU11274 Met Kinase Inhibitor,PKI-SU11274 Apoptosis , VEGFR , FGFR , c-Met/HGFR , CDK , Autophagy
SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.
T22259 AMG-Tie2-1 AMG-Tie2 Others
AMG-Tie2-1 is a dual inhibitor of VEGF receptor 2 (VEGFR2) and tunica interna endothelial cell kinase 2 (Tie2).
T36718 Tie2 Inhibitor 7
Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound c...
T68539 CEP-11981 BOL 303213X,ESK981 ; BOL 303213X,ESK981
CEP-11981 (ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI) that targets TIE2, VEGFR1-3, and FGFR1. It exhibits potential anti-tumor and anti-angiogenic effects.
T68286 CE-245677 mesylate
CE-245677 is a selective, orally active Tie2 kinase inhibitor identified by Pfizer previously in development for the treatment of certain cancers. CE-245,677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases w...
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